Andrew Garfield

Spider-Man / Peter Parker

Emma Stone

Gwen Stacy

Rhys Ifans

The Lizard / Dr. Curt Connors

Denis Leary

Captain Stacy

Martin Sheen

Uncle Ben

Sally Field

Aunt May

Irrfan Khan

Rajit Ratha

Campbell Scott

Richard Parker

Embeth Davidtz

Mary Parker

Chris Zylka

Flash Thompson

Max Charles

Peter Parker (Age 4)

C. Thomas Howell

Jack's Father

Jake Keiffer

Jack

Kari Coleman

Helen Stacy

Michael Barra

Store Clerk

Leif Gantvoort

Cash Register Thief

Andy Pessoa

Gordon

Hannah Marks

Missy Kallenback

Kelsey Asbille

Hot Girl

Kevin McCorkle

Mr. Cramer

Andy Gladbach

Physics Nerd

Ring Hendricks-Tellefsen

Physics Nerd

Barbara Eve Harris

Miss Ritter

Stan Lee

School Librarian

Danielle Burgio

Nicky's Girlfriend

Tom Waite

Nicky

Keith Campbell

Car Thief

Steve DeCastro

Car Thief Cop

Jill Flint

Receptionist

Mark Daugherty

OsCorp Intern

Milton González

Rodrigo Guevara

Skyler Gisondo

Howard Stacy

Charlie DePew

Philip Stacy

Jacob Rodier

Simon Stacy

Vincent Laresca

Construction Worker

Damien Lemon

Taxi Driver

Ty Upshaw

Police Officer with Sketch

James Chen

Police Officer

Alexander Bedria

Officer (SWAT)

Tia Texada

Sheila (Subway)

Jay Caputo

Subway Guy

John Burke

Newscaster (News Chopper)

Terry Bozeman

Principal

Jennifer Lyons

Second Girl (Subway)

Michael Massee

Man in the Shadows

Amber Stevens West

Ariel

Max Bogner

Scientist (uncredited)

Ethan Cohn

Lab Technician (uncredited)

Miles Elliot

Billy Connors (uncredited)

Miranda LaDawn Hill

Cheerleader (uncredited)

Amanda MacDonald

Goth Girl (uncredited)

Maury Morgan

Tina (uncredited)

Michael Papajohn

Alfie (uncredited)