Anna Faris

Cindy

Regina Hall

Brenda Meeks

Simon Rex

George

Anthony Anderson

Mahalik

Charlie Sheen

Tom

Leslie Nielsen

President Harris

Kevin Hart

CJ

Jeremy Piven

Ross Giggins

Pamela Anderson

Becca

Jenny McCarthy

Kate

Denise Richards

Annie

Elaine Klimaszewski

Elaine

Diane Klimaszewski

Diane

Drew Mikuska

Cody

Jianna Ballard

Sue

George Carlin

Architect

Queen Latifah

Aunt ShaNeequa

Marny Eng

Tabitha

Eddie Griffin

Orpheus

Camryn Manheim

Trooper Champlin

Timothy Stack

Carson Ward

Darrell Hammond

Father Muldoon

Dexter Bell

Toilet Guy

Dame Lee

Rapper #1

Doron Bell

Rapper #2

Simon Cowell

Simon Cowell

Fat Joe

Fat Joe

Ajay Naidu

Sayaman

William S. Taylor

Mr. Meeks

Patricia Idlette

Mrs. Meeks

David Edwards

Ralph

Frank C. Turner

Mr. Meek's Brother

Monica Dillon

Brenda's Grandmother

Lori Stewart

Tabitha's Mother

Jim Bremner

Guy in Chair

Phil Dornfeld

Tabitha's Voice (voice)

Edward Moss

MJ

Dee Jay Jackson

Zubie

D.L. Hughley

John Wilson

Ja Rule

Agent Thompson

Macy Gray

Macy Gray

Redman

Redman

Method Man

Method Man

Master P

Master P

Raekwon

Raekwon

RZA

RZA

U-God

U-God

Troy Yorke

Alien #1

Marco Soriano

Alien #2

Cliff Solomon

Native American #1

Byron Chief-Moon

Native American #2

Dolly Madsen

Native American #3

John Hainsworth

Tracheotomy Man

Beverley Breuer

Tracheotomy Wife

Jessie Young

Girl Scout

Deanne Henry

Tammy Fae Baker

Eric Breker

Secret Serviceman Jones

Naomi Lawson-Baird

Sweet Tabitha

Abigail Adams

Wedding Guest

Debbie Lee Carrington

Mini Tabitha (uncredited)

Tom Kenny

Alien (voice) (uncredited)

Frank Meschkuleit

Additional Performances (puppeteer)

Derek Stephen Prince

Alien (voice) (uncredited)