Tom Holland

Peter Parker / Spider-Man

Sadie Sink

Jean Grey

Tramell Tillman

William 'Bill' Metzger

Zendaya

MJ

Jon Bernthal

Frank Castle / Punisher

Jacob Batalon

Ned Leeds

Mark Ruffalo

Bruce Banner / Hulk

Liza Colón-Zayas

Detective Jean DeWolff

Florence Pugh

Yelena Belova / Black Widow

Marisa Tomei

May Parker

Naomi Watts

E.V. (voice)

Michael Mando

Mac Gargan / Scorpion

Keith David

Narrator of Spider Video (voice)

Marvin Jones III

Tombstone

Olivia Booth-Ford

Sara

Taryn Marie Butler

Apartment Girl

Johnny Myers

Building Manager

Billy Clements

Ramrod

Zabryna Guevara

Sheila Rivera

Nina Rose Galano

Marley

Maikol Roque

EJ

Jamel Davall Rodriguez

NYC Street Driver

Ethan Sokontwe

Scooter Kid

Tariyé Peterside

Tour Bus Guide

Phoenix Di Sebastiani

DODC Escort Guard

Vivien Keene

Female Janitor

Kurtis Lowe

DODC Box Guard

Marc Small

DODC Box Agent

David Hepple

Warehouse Worker

Jamaal Burcher

DODC Crew Chief

Lieve Carchon

Bathhouse Attendant

Mary Stillwaggon Stewart

Female DODC Guard

Luka Hays

DODC Weapons Tech

Camila López

Bodega Clerk

Robert Veng

Partygoer

Aoife Haakenson

Partygoer

Gabriel Blaikie

Partygoer

Eman Esfandi

The Boyfriend

Shing Moussa Chung

Building Tenant

Akil Young

Apartment Girl Boyfriend

Benedict Cezair-Thompson

DODC Substation Guard

Shannon Young Cho

Cindy

Niyi Akin

David

Carlos Agualusa

Businessman

Shelley Williams

Street Woman

Jud Charlton

Street Worker

John Moraitis

Balcony Guy

Beatriz Do O

Balcony Girl

Daisy Sequerra

Lucy (Bride)

Nezar Alderazi

John (Groom)

Daniel Kabanda

Cater-Waiter

Michael Magnet

Marriage Heli Pilot

Simon Schatzberger

Night Driver

Sean Carrington

DODC Tech

Anthony Nyro

DODC Prison Yard Guard

Michael Amariah

DODC Containment Guard

Fan Xiaoshuang

Snow

Elvis Carlos

Web Kid

Pat Kiernan

Pat Kiernan (uncredited)